Toward an architecture for quantum programming

It is becoming increasingly clear that, if a useful device for quantum computation will ever be built, it will be embodied by a classical computing machine with control over a truly quantum subsystem, this apparatus performing a mixture of classical and quantum computation. This paper investigates a possible approach to the problem of programming such machines: a template high level quantum language is presented which complements a generic general purpose classical language with a set of quantum primitives. The underlying scheme involves a run-time environment which calculates the byte-code for the quantum operations and pipes it to a quantum device controller or to a simulator. This language can compactly express existing quantum algorithms and reduce them to sequences of elementary operations; it also easily lends itself to automatic, hardware independent, circuit simplification. A publicly available preliminary implementation of the proposed ideas has been realized using the C++ language.Comment: 23 pages, 5 figures, A4paper. Final version accepted by EJPD ("swap" replaced by "invert" for Qops). Preliminary implementation available at: http://sra.itc.it/people/serafini/quantum-computing/qlang.htm

Contribution of introns to the species diversity associated with the apicomplexan parasite, Neospora caninum.

Neospora caninum is an intracellular parasite considered a leading cause of bovine reproduction failure worldwide, and a serious neurological disease of canines. Transplacental transmission in intermediate hosts is considered the most efficient means of transmission, which strictly involves asexual reproduction. Nonetheless, extensive genetic diversity has been reported within the species. What is yet to be elucidated are the major drivers of such diversity, and their impact on important parasite phenotypes such as virulence. Instead of protein-encoding sequences, genome and transcriptome data were used to investigate SNPs in introns between two distinct N. caninum isolates, with reported differences in pathogenicity. Variant analysis identified 840 and 501 SNPs within intergenic regions and introns, respectively, distinctly concentrated on chromosomes VI and XI, whereas the rest of the genome was monomorphic in comparison. Gene ontologies for SNP-dense intron-containing genes included ATP binding, transmembrane transport, protein kinase activity, and transcription and translation processes. This study shows that variation in non-coding DNA is contributing to N. caninum intraspecies genetic diversity, and potentially influencing and contributing to important parasite mechanisms. Finally, we present an assembled and annotated N. caninum apicoplast genome and show that this essential organelle is highly conserved between the two isolates, and related Coccidia

Spin-based optical quantum gates via Pauli blocking in semiconductor quantum dots

We present a solid-state implementation of ultrafast conditional quantum gates. Our proposal for a quantum-computing device is based on the spin degrees of freedom of electrons confined in semiconductor quantum dots, thus benefiting from relatively long decoherence times. More specifically, combining Pauli blocking effects with properly tailored ultrafast laser pulses, we are able to obtain sub-picosecond spin-dependent switching of the Coulomb interaction, which is the essence of our conditional phase-gate proposal. This allows us to realize {\it a fast two qubit gate which does not translate into fast decoherence times} and paves the road for an all-optical spin-based quantum computer.Comment: 14 Pages RevTeX, 3 eps figures include

Controlled collisions of a single atom and ion guided by movable trapping potentials

We consider a system composed of a trapped atom and a trapped ion. The ion charge induces in the atom an electric dipole moment, which attracts it with an r^{-4} dependence at large distances. In the regime considered here, the characteristic range of the atom-ion interaction is comparable or larger than the characteristic size of the trapping potential, which excludes the application of the contact pseudopotential. The short-range part of the interaction is described in the framework of quantum-defect theory, by introducing some short-range parameters, which can be related to the s-wave scattering length. When the separation between traps is changed we observe trap-induced shape resonances between molecular bound states and vibrational states of the external trapping potential. Our analysis is extended to quasi-one-dimensional geometries, when the scattering exhibit confinement-induced resonances, similar to the ones studied before for short-range interactions. For quasi-one-dimensional systems we investigate the effects of coupling between the center of mass and relative motion, which occurs for different trapping frequencies of atom and ion traps. Finally, we show how the two types of resonances can be employed for quantum state control and spectroscopy of atom-ion molecules.Comment: 17 pages, 16 figure

Genome wide identification of mutational hotspots in the apicomplexan parasite neospora caninum and the implications for virulence

© The Author(s) 2018. Neospora caninum is an apicomplexan parasite responsible for neosporosis, a disease causing hind limb paralysis in dogs and abortion in cattle, resulting in substantial economic losses to beef and dairy industries. Marked differences in pathogenicity exist between N. caninum strains suggesting that intrinsic genetic differences exist between them. These differences likely exist in genes expressed during the tachyzoite lifecycle stage which is responsible for the pathogenesis of neosporosis. An improved understanding of these genetic differences is essential to understanding N. caninum virulence, though such knowledge is scarce. Using a variant detection workflow we compared the tachyzoite transcriptomes of two N. caninum strains with different virulence properties: NC-Liverpool (virulent) and NC-Nowra (avirulent). This workflow identified 3130 SNPs and 6123 indels between the strains, and nine markers capturing 30 variants were Sanger sequenced for both strains. Sequencing of these loci was extended to an additional eight strains and subsequent phylogenetic analysis supported a genetic population structure comprised of two major clades with no geographical segregation. Sequence polymorphisms within coding regions of tachyzoiteassociated genes were concentrated on chromosomes XI and XII, with 19 distinct tachyzoite-associated SNP hotspot regions identified within coding regions of the N. caninum nuclear genome. The variants were predominantly located in loci associated with protein binding, protein-protein interactions, transcription, and translation. Furthermore, 468 nonsynonymous SNPs identified within protein-coding genes were associated with protein kinase activity, protein binding, protein phosphorylation, and proteolysis. This work may implicate these processes and the specific proteins involved as novel effectors of N. caninum tachyzoite virulence

Efficient and robust initialization of a qubit register with fermionic atoms

We show that fermionic atoms have crucial advantages over bosonic atoms in terms of loading in optical lattices for use as a possible quantum computation device. After analyzing the change in the level structure of a non-uniform confining potential as a periodic potential is superimposed to it, we show how this structure combined with the Pauli principle and fermion degeneracy can be exploited to create unit occupancy of the lattice sites with very high efficiency.Comment: 4 pages, 3 figure

Effect of layered double hydroxide intercalated with fluoride ions on the physical, biological and release properties of a dental composite resin

OBJECTIVES: The aim of this work was the preparation of a new fluoride-releasing dental material characterized by a release of fluoride relatively constant over time without any initial toxic burst effect. This type of delivery is obtained by a matrix controlled elution and elicits the beneficial effect of a low amount of fluoride on human dental pulp stem cells (hDPSCs) towards mature phenotype. METHODS: The modified hydrotalcite intercalated with fluoride ions (LDH-F), used as filler, was prepared via ion exchange procedure and characterized by X-ray diffraction and FT-IR spectroscopy. The LDH-F inorganic particles (0.7, 5, 10, 20wt.%) were mixed with a photo-activated Bis-GMA/TEGDMA (45/55wt/wt) matrix and novel visible-light cured composites were prepared. The dynamic thermo-mechanical properties were determined by dynamic mechanical analyzer. The release of fluoride ions in physiological solution was determined using a ionometer. Total DNA content was measured by a PicoGreen dsDNA quantification kit to assess the proliferation rate of hDPSCs. Alkaline phosphatase activity (ALP) was measured in presence of fluoride resins. RESULTS: Incorporation of even small mass fractions (e.g. 0.7 and 5wt.%) of the fluoride LDH in Bis-GMA/TEGDMA dental resin significantly improved the mechanical properties of the pristine resin, in particular at 37°C. The observed reinforcement increases on increasing the filler concentration. The release of fluoride ions resulted very slow, lasting months. ALP activity gradually increased for 28 days in hDPSCs cell grown, demonstrating that low concentrations of fluoride contributed to the cell differentiation. CONCLUSIONS: The prepared composites containing different amount of hydrotalcite filler showed improved mechanical properties, slow fluoride release and promoted hDPSCs cell proliferation and cell differentiation

Quantum point contact due to Fermi-level pinning and doping profiles in semiconductor nanocolumns

We show that nanoscale doping profiles inside a nanocolumn in combination with Fermi-level pinning at the surface give rise to the formation of a saddle-point in the potential profile. Consequently, the lateral confinement inside the channel varies along the transport direction, yielding an embedded quantum point contact. An analytical estimation of the quantization energies will be given